HHC-O: What are the effects of this cannabinoid?

HHC-O production

The cannabinoid HHC-O is produced by acylation, a special chemical reaction in which an acetyl group is added to the cannabinoid HHC via an acyl reagent, which may be acetyl chloride or acetic anhydride, to produce hexahydrocannabinol acetate (HHC-O).

This cannabinoid is not found in the cannabis plant at all and is produced in the laboratory. The addition of an acyl group enhances the overall potency of the cannabinoid, which can lead to a more intense high. 

HHC-O and the ECS system

The endocannabinoid system (ECS) is a complex system that performs a number of important functions in the human body. It contributes to the proper functioning of the liver, influences taste, mood and overall well-being. It is a complex system of cell signaling that regulates a variety of functions in the body, including the immune response.

Through endocannabinoids, enzymes and endocannabinoid receptors, the endocannabinoid system helps maintain the body's homeostasis. In addition, cannabinoids also interact well with the ECS and HHC-O is one of them. The interaction of HHC-O with the CB1 receptor in the brain induces states of relaxation and triggers psychoactive effects.

Studies suggest that ECS has positive effects on: 

  • Motor skills
  • Sleep
  • Skin health
  • Pain
  • Liver function
  • Memory
  • Metabolism
  • Taste
  • Bone growth
  • Mood
  • Heart health
  • Learning

Effects of HHC-O

The cannabinoid HHC-O is characterised by a slower onset of effects compared to the better known HHC. However, it always depends on the method of administration and the individual's particular disposition. The effects are longer lasting and more potent compared to HHC. 

The effects of both cannabinoids are very similar. Users mention that both HHC and HHC-O can induce withdrawal:

  • A feeling of relaxation
  • Induction of euphoric states
  • Deeper sleep
  • A more alert mind
  • Dampening of nausea
  • Helping to suppress chronic pain

Even with HHC-O, however, each user must beware of possible side effects. These include:

  • Dizziness
  • Paranoia
  • Insomnia
  • Rapid heart rate
  • Anxiety
  • Dry mouth
  • Redness of the eyes


Further research is necessary

The cannabinoid HHC-O has not yet been sufficiently researched by scientists and is not yet on the list of banned addictive substances in most countries around the world. The same is true in the Czech Republic. The status of this controversial substance may change rapidly. It is therefore also necessary to keep abreast of possible changes in legislation and to react skilfully to them. 

Because of the lack of regulation, it is also advisable to buy such products from reputable manufacturers. Only then can you be sure that your product is safe and correctly labelled. 

HHC-O products

Today, HHC-O cannabinoid is available in forms such as cartridges and in several different flavours. In addition, it can also be purchased in the form of oils, liquids, drops or gummies. HHC-O flowers or vaping pens are also available. 

It is clear that the range of HHC-O products continues to expand. At the same time, manufacturers often mix HHC-O with other cannabinoids to possibly complement or enhance the effects. In any case, it is advisable to start with a low dose when testing HHC-O products and, above all, to follow the manufacturer's recommendations.


HHC-O is a cannabinoid with great potential, and many users have been particularly impressed by its potent effects. In fact, these are estimated to be up to twice as potent compared to conventional HHC. The fact that the effects are not yet backed up by any scientific research, so it is not clear what the effects of HHC-O use are in the short or long term, is a disadvantage. This is also why users should approach HHC-O with caution. 



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